BioTek ADME/Tox Testing Solutions
BioTek manufactures microplate instrumentation solutions for in-vitro ADME/Tox testing applications, which enable higher throughput, decreased manual manipulations, and more consistent results. The compact footprint of the EL406 Combination Washer Dispenser and Precision Microplate Pipetting System allow for easy insertion into existing laminar flow hoods, allowing for sterile sample processing. For applications involving absorbance detection, the Epoch Microplate Spectrophotometer System provides an easy-to-use and efficient solution. Or for all detection modes, the Synergy line of multi-mode microplate readers are available.
See how our instruments can simplify your workflow, and explore various ADME/Tox applications below:
AbsorptionMetabolism
- Combining Luminescence-based CYP Inhibition Assays and Simple, Robust Instrumentation for Use in Automated Cytochrome P450 Profiling
- Automation of a Luminescent Assay to Measure UDP-glucuronosyltransferase (UGT) Enzyme Activity
- Automation of a Multiplexed Cell-based Assay to Measure Simultaneously Inhibition and Induction of the Cytochrome P450 Isoform 3A4 by Small Molecule Compounds
- Automated Triplexed Hepatocyte-Based Viability and CYP1A and CYP3A Induction Assays in 96- and 384-well Microplates
Toxicity
- Quantifying Cytotoxicity of Thiostrepton on Mesothelioma Cells using MTT Assay and the Epoch™ Microplate Spectrophotometer
- Automated Detection of Drug-Induced Lysosomal Cytotoxicity
- Fluorescent Detection of Drug-Induced Mitochondrial Toxicity
- Automated Drug-Induced Chromatin Condensation Detection
- Automated ApoTox-Glo Assay to Assess Cell Viability, Cytotoxicity and Apoptosis
- Invitrogen’s Predictor™ hERG Fluorescence Polarization Assay Using BioTek’s Synergy™ 4 Hybrid Microplate Reader